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Persistent fatigue may also be linked to vitamin B12 deficiency, vitamin D deficiency, thyroid disorders, autoimmune diseases, chronic pain conditions, and other chronic medical illnesses. “These conditions often require medical evaluation and treatment rather than simply sleeping longer,” said Dr. Kapil. Experts recommend seeking medical advice if fatigue lasts more than two to four weeks despite practicing good sleep hygiene, especially if it is accompanied by loud snoring, excessive daytime sleepiness, frequent headaches, memory or concentration problems, low mood or anxiety, and declining work or school performance.