Statins are among the world’s most commonly prescribed cholesterol-lowering medications, helping millions reduce their risk of heart attack, stroke, and cardiovascular disease. While they are highly effective and lifesaving, many patients report side effects like muscle pain, fatigue, or weakness, leading many to stop treatment without consulting their doctor. Now, a new study published in Science Advances has shed light on why these symptoms may occur, offering fresh insights that could improve the future of cholesterol treatment.